T'Challa was the first biological son of T'Chaka, King of the African Nation of Wakanda. His mother, N'Yami, died while giving birth and his adopted older brother, Hunter, blamed him for her death. His second mother, Ramonda, left the family when T'Challa was only eight. T'Chaka believed Ramonda had run away with another man, and so decreed that no one would speak of her in his presence again. Only decades later did T'Challa learn Ramonda had been kidnapped and brought back to her native South Africa.

T'Challa is a now Wakandan politician, the current ruler of Wakanda, and the current holder of the Black Panther mantle. After his father was killed in a bombing attack orchestrated by Zemo.